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Time-dependent changes in the mean arterial pressure (MAP) of angiotensin II (Ang II)-salt-induced hypertensive rats. Male Sprague-Dawley rats <t>with</t> <t>radio-telemetry</t> pressure transducers underwent surgery for the subcutaneous implantation of either saline- or Ang II-filled osmotic minipump. They received an intracerebroventricular injection of either phosphate-buffered saline (PBS)- or clodronate-liposomes and were provided with a high-salt diet (2.0% NaCl). The saline-salt treatment groups are represented by a dotted line, with PBS-liposome (open triangle) or clodronate-liposome (open circle). The Ang II-salt treatment groups are represented by a solid line, with PBS-liposome (solid triangle) or clodronate-liposome (solid circle). The numbers in parentheses indicated the number of rats tested; *p < 0.05 versus the rats receiving saline-salt treatment with PBS-liposome or clodronate-liposome; #p < 0.05 versus the rats receiving Ang II-salt treatment with PBS-liposome.
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Time-dependent changes in the mean arterial pressure (MAP) of angiotensin II (Ang II)-salt-induced hypertensive rats. Male Sprague-Dawley rats <t>with</t> <t>radio-telemetry</t> pressure transducers underwent surgery for the subcutaneous implantation of either saline- or Ang II-filled osmotic minipump. They received an intracerebroventricular injection of either phosphate-buffered saline (PBS)- or clodronate-liposomes and were provided with a high-salt diet (2.0% NaCl). The saline-salt treatment groups are represented by a dotted line, with PBS-liposome (open triangle) or clodronate-liposome (open circle). The Ang II-salt treatment groups are represented by a solid line, with PBS-liposome (solid triangle) or clodronate-liposome (solid circle). The numbers in parentheses indicated the number of rats tested; *p < 0.05 versus the rats receiving saline-salt treatment with PBS-liposome or clodronate-liposome; #p < 0.05 versus the rats receiving Ang II-salt treatment with PBS-liposome.
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Time-dependent changes in the mean arterial pressure (MAP) of angiotensin II (Ang II)-salt-induced hypertensive rats. Male Sprague-Dawley rats with radio-telemetry pressure transducers underwent surgery for the subcutaneous implantation of either saline- or Ang II-filled osmotic minipump. They received an intracerebroventricular injection of either phosphate-buffered saline (PBS)- or clodronate-liposomes and were provided with a high-salt diet (2.0% NaCl). The saline-salt treatment groups are represented by a dotted line, with PBS-liposome (open triangle) or clodronate-liposome (open circle). The Ang II-salt treatment groups are represented by a solid line, with PBS-liposome (solid triangle) or clodronate-liposome (solid circle). The numbers in parentheses indicated the number of rats tested; *p < 0.05 versus the rats receiving saline-salt treatment with PBS-liposome or clodronate-liposome; #p < 0.05 versus the rats receiving Ang II-salt treatment with PBS-liposome.

Journal: JMA Journal

Article Title: Macrophage Depletion by Intracerebroventricular Administration of Clodronate-Liposome Attenuates the Development of Angiotensin II-Salt-Induced Neurogenic Hypertension in Rats

doi: 10.31662/jmaj.2025-0203

Figure Lengend Snippet: Time-dependent changes in the mean arterial pressure (MAP) of angiotensin II (Ang II)-salt-induced hypertensive rats. Male Sprague-Dawley rats with radio-telemetry pressure transducers underwent surgery for the subcutaneous implantation of either saline- or Ang II-filled osmotic minipump. They received an intracerebroventricular injection of either phosphate-buffered saline (PBS)- or clodronate-liposomes and were provided with a high-salt diet (2.0% NaCl). The saline-salt treatment groups are represented by a dotted line, with PBS-liposome (open triangle) or clodronate-liposome (open circle). The Ang II-salt treatment groups are represented by a solid line, with PBS-liposome (solid triangle) or clodronate-liposome (solid circle). The numbers in parentheses indicated the number of rats tested; *p < 0.05 versus the rats receiving saline-salt treatment with PBS-liposome or clodronate-liposome; #p < 0.05 versus the rats receiving Ang II-salt treatment with PBS-liposome.

Article Snippet: Radio-telemetry pressure transducers (Data Sciences International, Arden Hills, MN, USA), consisting of a fluid-filled catheter attached to a PA-C40 transmitter, were implanted into the abdominal aorta as described previously .

Techniques: Saline, Injection, Liposomes